7.1 |
Class: SMAD/NF-1 DNA-binding domains (SMAD/NF-1), Alignment |
Note: The two families of this class share only little sequence similarities. Therefore, the sequence aligments of their DNA-binding domains will be listed separately for the SMAD family (7.1.1) and the NF-1 family (7.1.2). |
Aligned SMAD DNA-binding domain sequences (Family 7.1.1): |
Note that many factors of this family have two or three repeats of myb type, which have been separately aligned and consecutively numbered. |
PAVKRLLGWK-------------QGDEEEKWAEKAVDALVKKLKKKKG-AMEELE---KALSCPG-QPSNCVTIP------------------------------RSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECC-EFPFGSKQKEVCINPYHYKRVESPVLP SMAD1
PVVKRLLGWKKSAGGSGGAGGGEQNGQEEKWCEKAVKSLVKKLKKT-G-RLDELE---KAITTQN-CNTKCVTIPSTCSEIWGLSTPNTIDQWDTTGLYSFSEQTRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELKAIENC-EYAFNLKKDEVCVNPYHYQRVETPVLP SMAD2
PIVKRLLGWKK----------GEQNGQEEKWCEKAVKSLVKKLKKT-G-QLDELE---KAITTQN-VNTKCITIP------------------------------RSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELRAMELC-EFAFNMKKDEVCVNPYHYQRVETPVLP SMAD3
PAVKRLLGWK-------------QGDEEEKWAEKAVDALVKKLKKKKG-AMEELE---KALSSPG-QPSKCVTIP------------------------------RSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLDIC-EFPFGSKQKEVCINPYHYKRVESPVLP SMAD5
PAVKRLLGWK-------------QGDEEEKWAEKAVDSLVKKLKKKKG-AMDELE---RALSCPG-QPSKCVTIP------------------------------RSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECC-EFPFGSKQKEVCINPYHYRRVETPVLP SMAD9
SIVHSLMCHR-------------QGGESETFAKRAIESLVKKLKEKK----DELDSLITAITTNGAHPSKCVTIQ------------------------------RTLDGRLQVAGRKGFPHVIYARLWRWPDLH-KNELKHVKYC-QYAFDLKCDSVCVNPYHYERVVSPGID SMAD4
AALEPAGGGR----------SREARSRLLLLEQELKTVTYSLLKRLKERSLDTLLE--AVESRGG-VPGGCVLVP------------------------------R-ADLRLG--GQPAPPQLLLGRLFRWPDLQHAVELKPLCGCHSFAAAADGPTVCCNPYHFSRLCGPESP SMAD6
KAVRGAKGHHHPHPPAAGAGAAGGAEADLKALTHSVLKKLKERQLELLLQAVESRGGTRTACLLLPGRLDCRLGP-----------------------------GAPAGAQPAQPPSSYSLPLLLCKVFRWPDLRHSSEVKRLCCCESYG-KINPELVCCNPHHLSRLCELESP SMAD7
Aligned NF-1 DNA-binding domain sequences (Family 7.1.2): |
-MYSPLCLTQDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKEEERAVKDELLSEKPEVKQKWASRLLAKLRKDIRPEYREDFVLTVTGKKPPCCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLVKSPQCSNPGLCVQPHHIGVSVKELDLYLAYFVHAADSSQSESP NF1A
MMYSPICLTQDEFHPFIEALLPHVRAIAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLSEKPEIKQKWASRLLAKLRKDIRQEYREDFVLTVTGKKHPCCVLSNPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQPHHITVSVKELDLFLAYYVQEQDSGQSGSP NF1B
MYSSPLCLTQDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLGEKPEVKQKWASRLLAKLRKDIRPECREDFVLSITGKKAPGCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLVKAAQCGHPVLCVQPHHIGVAVKELDLYLAYFVRERDAEQSGSP NF1C
-MYSPYCLTQDEFHPFIEALLPHVRAFSYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLGEKPEIKQKWASRLLAKLRKDIRPEFREDFVLTITGKKPPCCVLSNPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLYKSPQCSNPGLCVQPHHIGVTIKELDLYLAYFVHTPESGQSDSS NF1X